CAS No. 1143-70-0 Urolithin A for Health, Cosmetics Use

Product Overview

Urolithin A (CAS No. 1143-70-0) is a naturally occurring bioactive metabolite derived from ellagic acid and ellagitannins found in fruits such as pomegranates, strawberries, raspberries, blackberries, and walnuts. It is produced in the human body through gut microbiota metabolism and has gained strong scientific attention for its antioxidant, anti-inflammatory, and mitochondrial-supporting properties.

It is widely applied in dietary supplements, cosmetic formulations, pharmaceutical research, and sports nutrition due to its potential role in supporting healthy aging and cellular function.

Background and Natural Source of Urolithin A

Urolithin A is not directly present in foods but is formed after the intake of ellagic acid–rich plants. Once consumed, ellagic acid is metabolized by intestinal microbiota into a series of urolithins, with Urolithin A being the most active and well-studied form.

Natural precursor sources include:

• Pomegranate

• Strawberries

• Raspberries

• Blackberries

• Walnuts

However, the ability to produce Urolithin A varies significantly among individuals due to differences in gut microbiota composition. This has increased interest in direct supplementation and standardized production.

Production and Synthesis of Urolithin A

Urolithin A CAS No. 1143-70-0 can be obtained through both biological and chemical methods depending on application requirements.

Microbial Biotransformation Pathway

In the human body, Urolithin A is formed through a multi-step microbial conversion process:

1. Ellagic acid is released from dietary polyphenols

2. Gut bacteria metabolize it into intermediate urolithins

3. Enzymatic reactions produce Urolithin A

Beneficial bacteria such as Lactobacillus and Bifidobacterium species may contribute to this transformation process.

Chemical Synthesis Method

For industrial applications, Urolithin A can also be produced via chemical synthesis starting from aromatic compounds through hydroxylation, cyclization, and purification processes.

Advantages include:

• High purity output

• Stable batch consistency

• Scalable industrial production

• Suitable for pharmaceutical and cosmetic use

Key Biological Functions and Mechanisms

Strong Antioxidant Activity

Urolithin A helps neutralize free radicals and reduce oxidative stress, protecting cells from damage. Oxidative stress is linked to aging and chronic diseases such as cardiovascular and neurodegenerative disorders.

Anti-Inflammatory Effects

Urolithin A can regulate inflammatory responses by reducing pro-inflammatory cytokines, supporting:

• Joint health

• Cardiovascular function

• Immune balance

• Metabolic health

Mitochondrial Health and Autophagy Activation

One of the most important mechanisms of Urolithin A is its ability to promote mitophagy, a cellular process that removes damaged mitochondria and supports energy renewal.

This may contribute to:

• Improved cellular energy production

• Enhanced muscle endurance

• Better metabolic efficiency

• Healthy aging support

Applications of Urolithin A CAS No. 1143-70-0

Dietary Supplements and Nutraceuticals

Urolithin A is widely used in formulations targeting:

• Healthy aging support

• Muscle performance

• Cellular energy metabolism

• Antioxidant protection

Cosmetics and Skincare

In skincare applications, Urolithin A is valued for reducing oxidative stress and inflammation, supporting skin vitality and anti-aging performance.

Common uses include:

• Anti-aging creams

• Repair serums

• Skin barrier support products

• Brightening formulations

Pharmaceutical and Biomedical Research

Urolithin A is actively studied for its potential role in:

• Neurodegenerative diseases (Alzheimer’s, Parkinson’s)

• Mitochondrial dysfunction

• Age-related muscle decline

• Metabolic disorders

Sports Nutrition

Urolithin A is also explored in sports nutrition for its potential to improve endurance and reduce fatigue, especially in aging populations.

Benefits may include:

• Enhanced muscle performance

• Reduced exercise fatigue

• Improved recovery

• Better mitochondrial efficiency

Product Advantages

Urolithin A CAS No. 1143-70-0 offers multiple advantages:

• High purity and stable quality

• Strong scientific research support

• Multi-industry applicability

• Suitable for advanced formulations

• Growing global market demand

Conclusion

Urolithin A CAS No. 1143-70-0 is a highly promising natural bioactive compound derived from ellagic acid metabolism. It demonstrates strong antioxidant, anti-inflammatory, and mitochondrial-supporting properties, making it a valuable ingredient in modern health, cosmetic, and pharmaceutical industries.

With increasing scientific interest in cellular health and longevity, Urolithin A is expected to play an increasingly important role in future functional nutrition and anti-aging product development.